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Officers were called to the 1800 block of Boas Street around 9 p.m. on a report of a domestic incident involving a gun, Harrisburg police said.
Once inside, they found the woman's body with multiple gunshot wounds.
Police have a person of interest in custody for questioning.
The investigation is ongoing.
Anyone with information is asked to contact the Harrisburg Police at 717-558-6900. Tips and information can also be submitted via the CRIMEWATCH website.
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